Abstract

AbstractFrom a study of the 13C‐shift values of the MTPA esters of 3‐substituted cyclohexanols of known absolute configuration an empirical rule has been developed to determine the absolute configuration of chiral cyclohexanols. The method is based on the Dale–Mosher model, which was originally developed for 1H‐NMR spectra. The scope and limitations of this method are discussed. The enantiomeric purity of the alcohols can be determined simultaneously by integration of the signals in well‐resolved diastereotopic carbon pairs.

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