Determination of the 90% effective dose of intranasal dexmedetomidine for sedation during electroencephalography in children.

Abstract

The intranasal route of dexmedetomidine (DEX) administration is becoming increasingly popular for providing adequate sedation during short examinations in infants and children. However, data on the 90% effective dose (ED90) of intranasal DEX are rare in children under 3years old. This is a double-blind trial using a biased coin design up-and-down sequential method (BCD-UDM). Fifty-three children aged under 3years old requiring DEX for EEG were included in our study. The first patient received 2.5μgkg-1 DEX, and the dose of DEX administered to the subsequent patient was determined by the response of the previous patient. The patient responses were recorded and analysed to calculate the ED90 by isotonic regression. The 95% confidence interval (CI) was estimated using a bootstrapping method. Fifty-three patients were included in our study, of which 45 patients were successfully sedated, and the 8 instances of failed sedation were rescued using sevoflurane inhalation, allowing the completion of the procedure. The 90% effective dose of DEX was calculated to be 3.28µgkg-1 , and the 95% CI was 2.74~3.39µgkg-1 . No significant adverse events occurred in any of the patients. The 90% effective dose of intranasal DEX sedation for EEG was 3.28μgkg-1 in children under 3years old.