Determination of sulfonamides in milk and egg samples by HPLC with mesoporous polymelamine-formaldehyde as magnetic solid-phase extraction adsorbent.

Abstract

In this work, magnetic mesoporous polymelamine-formaldehyde composites were synthesized via a facile Schiff base reaction. The magnetic mesoporous polymelamine-formaldehyde composites combined both the properties of mesoporous polymelamine-formaldehyde and the magnetism of NH2 -SiO2 @Fe3 O4 nanoparticles, possessing high specific surface area (150.66 m2 g-1 ) and good magnetism (24.50 emu g-1 ). The magnetic mesoporous polymelamine-formaldehyde composites were employed as magnetic adsorbent for the extraction of sulfonamides. Under optimal conditions, good linearities with correlation coefficients higher than 0.9984 were obtained between peak area and sulfonamides concentration (2-200 μg L-1 ) with limits of detection in the range of 0.33-0.58 μg L-1 . The established method was successfully applied for the determination of sulfonamides in egg and milk samples. The adsorption mechanisms demonstrated that the adsorption of magnetic mesoporous polymelamine-formaldehyde composites toward sulfonamides was a multilayer process, and adsorption kinetics followed the pseudo-second-order model.