Abstract
In this work, it was used a polypyrrole (PPy) electrode as a potentiometric electrochemical detector in a flow injection system in order to determine sulfamethoxazole in pharmaceutical formulations. The PPy electrode was prepared by cyclic voltammetry in acetonitrile solution. A linear relationship was observed over the concentration range of 2.5 × 10-5-1.25 × 10-3 mol L-1 with a correlation coefficient of 0.9977 and limit of detection (LOD) of 1.03 × 10-6 mol L-1 (S/N = 3). The recoveries in tablet and syrup formulations were found as 97.4 and 90.8% with the relative standard deviations of 0.62 and 1.04%, respectively, which closely agree with those measured by high performance liquid chromatography (HPLC) with UV detector. Therefore, it was concluded that the PPy electrode can be used as an alternative novel potentiometric detector material for determination of sulfamethoxazole in pharmaceuticals with the advantages of easy preparation and regeneration capability of the electrode surface.
Highlights
In recent years, the research activities on the potentiometric sensor with nanomolar or subnanomolar detection limits in the literature have increased.[1,2] Bakker and Pretsch[3] reviewed recent progress in the development and application of potentiometric sensors
A potentiometric detector that is based on membrane electrodes offers an attractive alternative in high performance liquid chromatography (HPLC) and capillary electrophoresis (CE) for determination of organic cations.[6,7,8,9,10]
The results showed that there was no significant difference between the proposed and HPLC-UV method
Summary
The research activities on the potentiometric sensor with nanomolar or subnanomolar detection limits in the literature have increased.[1,2] Bakker and Pretsch[3] reviewed recent progress in the development and application of potentiometric sensors. Rubinova et al.[4] used a potentiometric sensor based on polymer membranes with a limit of detection (LOD) of nanomolar range. Szigeti et al.[5] reported a novel potentiometric and optical sensors for silver ion with a limit of detection of subnanomolar. In contrast to amperometric detectors,[13,14] the response of potentiometric detector is quasi-independent
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