Abstract
Structural characteristics of O-(2-hydroxypropyl)cellulose samples, namely the molar substitution (mol. subst.), the total degree of substitution (d.s.), and the individual degree of substitution of hydroxyl groups on the glucose residues for a wide mol. subst. range of samples were determined after peracetylation by 1H- and 13C-n.m.r. analyses. The mol. subst. value was determined by comparing the acetyl methyl proton signal with that of the 2-hydroxypropyl methyl group. The acetyl carbonyl carbon signal of acetylated O-(2-hydroxypropyl)cellulose samples was found to split into a quadruplet in Me 2SO at 100°, reflecting the position of the substituent (2, 3, and 6) on the glucose residue and of the (oligo-)propylene oxide substituent end-group, and allowing determination of the substituent distribution as well as the total degree of substitution in a series of O-(2-hydroxypropyl)cellulose samples.
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