DETERMINATION OF SOME INDICATORS OF CELLULAR IMMUNITY IN DOGS WITH DEEP PYODERMIA

Abstract

The article presents the results of determining of selected indicators of cellular immunity in dogs with deep pyoderma.. As the research results showed, the total content of leukocytes in animals with pyoderma was 11.84 ± 1.06 G/l, which was 1.19x109/l higher than the similar indicator of healthy animals. An increase in the content of leukocytes was caused by neutrophilia. As was established that the absolute neutrophils count in animals with generalized pyoderma significantly exceeded the similar indicator of healthy animals of the control group (< 0.05), at the same time, the content of lymphocytes and eosinophils was higher in animals of the control group and amounted to 2.98 ± 1.16 and 0.64 ± 0.11, respectively. It was also established that in dogs with deep generalized pyoderma, suppression of the activity of a number of key elements of cellular immunity was observed: indicators of phagocytosis, content of blood T-lymphocytes. The number of T-helper cells in dogs of the control group exceeded the similar indicator of animals with pyoderma, while the content of T-suppressors was higher in affected animals, which indicates the development of moderate immunosuppression. The obtained results indicate a necessity for further study of the cellular immunity of dogs with pyoderma in order to develop novel protocols for the treatment of animals with the use of means of immunocorrection.