Abstract
Heavy metals may be harmful to human health over the short and long term. Consumption of fish, one of the most important sources of protein in human life is one of the most common ways of heavy metal exposure. In this study for determine some heavy metals (Li, Na, Mg, Al, K, Ca, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Ag, Cd, Pb and U) concentration in different tissues as muscle, liver and gill of common carp (Cyprinus carpio, L., 1758) and pike barb (Luciobarbus esocinus, H., 1843) collected from Karasu River (Erzincan, Turkey) along the upper Euphrates Basin were collected between November 2019 and October 2020 on monthly. Heavy metal analysis was performed by ICP-MS -Bruker 820-MS. The results of heavy metals in tissues were compared to acceptable international limits. 
 The studied metals were found at a considerable level in all seasons, indicating that the Karasu River biota is particularly vulnerable to heavy metal intake. Consequently, research has shown a strong connection between various elements and in addition, the human health risk assessment (HHRA) reveals are hazardous for consumption of fish.
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