Abstract
In this paper, we present a technique for determining the solubility of both stable and metastable polymorphs. The technique was developed during a study of the thermodynamic relationships, between the polymorphic forms of carbamazepine (forms I and III), glycine (α and γ forms), and mefenamic acid (forms I and II), using a Mettler Toledo 822e differential scanning calorimeter (DSC). The three systems under investigation were found to be enantiotropic with transition points at 78 °C (carbamazepine), 177 °C (glycine), and 86.6 °C (mefenamic acid). Solubility determination of the metastable polymorphic form of the systems was carried out by slow heating (0.08 K/min) of the sample, and using heat flow derivative curves, where the saturation point and hence the solubility at a known weight percentage are given by the peak of a heat flow curve.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
