Abstract
The SOD-like activity of the copper(II) complexes of five amino acid (Gly, Ala, Ser, Asn, Glu) dithiocarbamates was determined. The concentration of the complexes that inhibit by 50% (IC 50) the reduction of nitroblue tetrazolium by superoxide radical (generated by xanthine oxidase) lies between 1.2 μM (Glu) and 20 μM (Gly). Quantitative structure-activity relationships, QSAR, were established between pIC 50 (-log IC 50) and the molar refraction values of the amino acid substituents, as well as Cu(I) / Cu(II) oxidation potentials (determined by cyclic voltammetry). The high SOD-like activity of the Glu dithiocarbamate complex is interpreted to be due to its distorted geometry based on EPR spectra and conductimetric titration data.
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