Abstract
Purpose To determine the frequency of the genotype of signal transducer and activator of transcription protein 3 (STAT3) rs744166, sirtuin (SIRT1) rs12778366, fibroblast growth factor (FGFR2) rs2981582, and advanced glycosylation end product-specific receptor (RAGE) rs1800625 gene polymorphisms in patients with laryngeal squamous cell carcinoma (LSCC). Methods A total of 944 subjects were evaluated, which includes 144 patients with LSCC and 800 healthy controls. The genotyping of STAT3 rs744166, SIRT1 rs12778366, FGFR2 rs2981582, and RAGE rs1800625 was carried out using the RT-PCR. Results The analysis of STAT3 rs744166, SIRT1 rs12778366, and FGFR2 rs2981582 gene polymorphisms did not reveal any differences in genotype distribution between the patients with LSCC and the control subjects. However, statistical analysis revealed that genotypes (AA, AG, and GG) of rs1800625 in RAGE gene were distributed statistically significantly differently between patients and controls (61.1%, 30.6%, and 23.6% vs. 72.5%, 25.8%, and 1.8%, respectively; p < 0.001). Additionally, statistical significance was observed in allele distribution between these two groups, i.e., allele G at rs1800625 was more frequently observed in the patient group than in controls (23.6% vs. 14.6%; p < 0.001). Conclusion RAGE rs1800625 gene polymorphism may play a significant role in laryngeal squamous cell carcinoma development.
Highlights
The TNM classification for cancers of the head and neck includes tumors of the nasal cavities, paranasal sinuses, oral cavity and larynx, nasopharynx, oropharynx, and hypopharynx [1]
The aim of this study was to determine the possible involvement of STAT3, SIRT1, Fibroblast growth factor receptor 2 (FGFR2), and receptor for advanced glycosylation end products (RAGE) gene polymorphisms in Laryngeal squamous cell carcinoma (LSCC) patients as to the best of our knowledge, all these four gene polymorphisms are studied for the first time in LSCC patients
Our study results showed that genotypes (AA, AG, and GG) of rs1800625 in RAGE gene were distributed statistically significantly differently between patients and controls (61.1%, 30.6%, and 8.3% vs. 72.5%, 25.8%, and 1.8%, respectively; p < 0:001) and allele G at rs1800625 was more frequently observed in Control n = 144 n = 800
Summary
The TNM classification for cancers of the head and neck includes tumors of the nasal cavities, paranasal sinuses, oral cavity and larynx, nasopharynx, oropharynx, and hypopharynx [1]. Despite the improvements in surgical techniques, chemotherapy, and radiotherapy, the 5-year survival rates remain less than 60% [4]. The environmental factors that are reported to be associated with the increased risk of LSCC include smoking, alcohol consumption, exposure to carcinogens in the work environment, nutrition, and viral infections with human papilloma virus (HPV) and Epstein-Barr virus (EBV) [6,7,8,9,10,11]. In the last years, increasing interest has been focused on the role of gene polymorphisms in cancer development and progression [8, 12, 13]
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