Abstract
For pores which can adopt only the open and closed states, the influence of the amplitude distribution of the single-pore conductance (γ, open state) on the covariance function is derived. It is shown that reliable mean values of γ ( E(γ)) can be derived from noise analysis only if the variance in the amplitude distribution (σ γ 2) is known. In the past, σ γ 2 was set always to zero, leading to an overestimation of E(γ). In the case of gramicidin-doped lipid bilayer membranes, this overestimation amounts to as much as 15% of the true value of E(γ).
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