Abstract
A method for the simultaneous measurement of serum testosterone (T) and androstanediol (Ad) utilizing aluminum oxide thin layer chromatography and competitive protein binding analysis is presented. The method separates not only T from Ad, but also the androstanediol isomers. The primary Ad found was 5α-androstane-3α, 17β diol. Levels of both Steroids were determined in normal adults and children, and in a variety of endocrine disorders. The average T Ad ratio was higher in female children than other controls except adult males. However, results were too variable and number of patients insufficient to draw definite conclusions as to the value of determination of this ratio in patients with androgen disorders.
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