Abstract
A method for the determination of selenium by ion chromatography (IC) after oxygen flask combustion has been developed and applied to the determination of selenium in bulk prednisolone. We found elemental selenium [Se(O)], selenite ion [Se(IV)] and selenate ion [Se(VI)] (ca. 5,75 and 20%) in the absorbing liquid obtained by oxygen flask combustion of Se(0), Se(IV) and Se(VI). Se(VI) was directly determined by IC. Se(IV) was determined as Se(VI) after oxidation by potassium permanganate. Se(0) was oxidized to Se(VI) by hydrogen peroxide and potassium permanganate. In this method, the recovery of selenium was in the range of 95 -100%, and the detection limit was 63 ng (79 pg with concentrator) in 40 mg of sample.
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