Abstract
Determination of Safety Margin for Hepatotoxic Effect of Mentha Longifolia Essential Oil in Rat
Highlights
Mentha longifolia is one of the aromatic medicinal plant belongs to Lamiaceae family
Twentyeight components were identified in the essential oil of M. longifolia
We were going to define the maximum dose of essential oil of M. longifolia (EOML), which did not show any hepatic deterioration as a safety remark
Summary
Mentha longifolia is one of the aromatic medicinal plant belongs to Lamiaceae family. There are some active ingredients in the essential oil of M. longifolia, which potentially could impair the hepatic function. The aim of this study was to find the maximum dose of essential oil of M. longifolia (EOML) that does not show any hepatic deterioration. After the completion of administration, the serum activity of ALT, AST, and ALPas the well-known liver toxicity enzymes and the serum total billirubine were measured, by spectrophotometer. Conclusion: The essential oil of M. longifolia is not entirely safe especially for the liver. Administration at the dose of 400 mg/kg leads to the hepatotoxic effect. The possible mechanisms for the EOML liver toxicity are triggering of oxidative stress or apoptosis by its ingredient like pulegone compound.
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