Determination Of Risk Parameters In The Detection Of Asymptomatic Bone Metastases Of Kidney And Prostate Cancer

Abstract

Using multivariate analysis to identify predictive risk parameters in the diagnosis of asymptomatic osteogenic metastasis of renal and prostate cancer. The work was based on the results of observations of 105 patients with a morphologically confirmed diagnosis of malignant neoplasm registered at the Republican Specialized Scientific and Practical Center of Oncology and Radiology (RSNPMTSO and R) and the Samarkand branch. In 62 patients with kidney cancer (RP) included in the study, the mean age of patients with RP was 58.3 years. 43 patients with prostate cancer (PC) were included in the study, the average age of patients with PC was 68 years. We analyzed such parameters as age, stage of the disease, timing of detection of bone metastasis (BM), prevalence, type and size of BM, as well as additional criteria: in case of prostate cancer - the size of the primary tumor and the degree of malignancy, in case of prostate cancer - the sum of points on the Gleason scale and the prostate -specific antigen (PSA). It was revealed that the highest risk in detecting BM in RP was noted for the stage of the disease, p = 0.006. Also, a high risk was associated with the size and grade of tumor malignancy, with CR at p = 0.006 and p = 0.008, respectively. Among the listed, the highest risk in detecting BM is observed in prostate cancer for the stage of the disease (p = 0.001). In addition, an increased risk was observed for the Gleason score and PSA level (p = 0.013 and p = 0.008, respectively). Thus, during the 2-year follow-up, BM most often develops in patients with kidney cancer at stage Tv-T3a stage and with grade G III and in patients with prostate cancer - in the presence of stage III with a Gleason score of ≥ 7 and a level PSA in the range of 21-50 ng / ml.