Determination of resistance pattern of bacteriostatic antimicrobial drugs by analysis of blood culture reports

Abstract

Background: Determination of each isolated bacterium from blood culture and pattern of antimicrobial sensitivity has an important role epidemiologically in a region and can assist physicians in the determination of primary antimicrobial agents. In this study, schema of resistance of bacteriostatic antimicrobials in blood culture is evaluated. Determination of resistance pattern of bacteriostatic antimicrobial drugs by analysis of blood culture report.Methods: A retrospective analysis of microbiological blood culture and antibiotics sensitivity results have been done. A total of 120 laboratory culture results were selected randomly during the observational period. These all-blood culture reports were analyzed for bacteriostatic antimicrobial resistance pattern.Results: The 41 bacterial isolates were obtained from 120 blood culture reports, 24.39% (10) were gram positive and 75.60% (31) were gram-negative. The most frequently isolated gram-negative organisms were K. pneumoniae (34.14%) followed by Pseudomonas (12.19%), E. coli (12.19%). The most frequently isolated gram-positive organism was staphylococcus aureus. All isolates showed less resistance to bacteriostatic antibiotics like clindamycin, chloramphenicol, co-trimoxazole, doxycycline, linezolid, tetracycline, nitrofurantoin, erythromycin, tigecycline.Conclusions: S. aureus, E. coli and Klebsiella spp. pseudomonas aeruginosa were the leading causes of septicaemia or any type of infection in our study finding. These bacteria isolates were highly resistant to bactericidal antimicrobials. But bacteriostatic antimicrobial has shown less resistance compared to bactericidal.