DETERMINATION OF RADIOLOGICAL PARAMETERS OF SOME ACTIVE PHARMACEUTICAL INGREDIENTS USING WINXCOM SOFTWARE IN THE ENERGY RANGE 1KEV TO 100KEV

Columbus Tobechukwu Eze,Philibus Musa Gyuk,Suleiman Isah,Arome Aruwa,Ashibi Martha Ali Adejo,Achor Mathias Ogwo

doi:10.29121/ijoest.v5.i5.2021.208

Columbus Tobechukwu Eze, Philibus Musa Gyuk + Show 4 more

Open Access

https://doi.org/10.29121/ijoest.v5.i5.2021.208

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Abstract

The effective atomic number, electron density and mass attenuation coefficient of some selected active pharmaceutical ingredients such as Diclofenac Sodium, Femotidine, Alprazolam, Amiodar, Amiodarone, Ciprofloxacin, and Nimesulide have been calculated over the energy range from 1 keV to 100 GeV for total and partial photon interactions by using WinXCom. The obtained data shows that the change in mass attenuation coefficient and electron density varies with energy and chemical composition of the active pharmaceutical ingredients (API’s) in drugs. The results in the variation of photon interaction with energy and effective atomic number of the API’s in drug are shown in the logarithmic graphs.

Highlights

DETERMINATION OF RADIOLOGICAL PARAMETERS OF SOME ACTIVE PHARMACEUTICAL INGREDIENTS USING WINXCOM SOFTWARE IN THE ENERGY RANGE 1KeV TO 100GeV
The mass attenuation coefficients are widely used in the calculation of the photon penetration and the energy deposition in biological shielding and other dosimetric materials. The application of such effective atomic number can be described in two ways (i) the effective atomic number can be put into formulae and in this way a compound can be reduced to an ordinary element, if calculation of Z-dependent effects are to be carried out and (ii) the effective atomic number can be used to find compound with atomic composition like air or water, etc
The photon mass attenuation coefficient for any chemical compounds or a mixture can be written as μμ ρρ = ∑ii wwii μμ ρρ ii

Summary

INTRODUTION

Mass Attenuation Coefficients (μ/ρ), Effective atomic number (Zeff) and Electron Density (Nel) are important parameters in determining the interactions of X-rays and gamma photons in matter (Manohara and Hanagodimath (2007). The mass attenuation coefficients are widely used in the calculation of the photon penetration and the energy deposition in biological shielding and other dosimetric materials The application of such effective atomic number can be described in two ways (i) the effective atomic number can be put into formulae and in this way a compound can be reduced to an ordinary element, if calculation of Z-dependent effects are to be carried out and (ii) the effective atomic number can be used to find compound with atomic composition like air or water, etc. The aim of this work is to calculate the total attenuation cross sections as well as the composition dependent quantities such as effective atomic number (Zeff) and effective electron densities (Ne) of active pharmaceutical ingredients and to have a full understanding of the nature of interaction of active pharmaceutical ingredients (API) over some energy range

METHODOLOGY

RESULTS AND DISCUSSION

CONCLUSION