Abstract
Quinine is a highly active blood schizontocide and is still used in the treatment of P. fulciparum malaria resistant to chloroquine or other antimalarial drugs. For its determination, most pharmacopoeias recommend non-aqueous titration [l-3] or an extractionweighing method [l]. Other methods that have been proposed include spectrophotometry [4], fluorimetry [5], liquid chromatography [6] and ion-selective electrode potentiometry [7]. The conventional extraction-weighing method which is based on neutralization, extraction, evaporation and weighing the quinine base is time-consuming and rather inconvenient; in addition a relatively large sample is required. The piezoelectric quartz crystal is very sensitive for weight determination and is widely used as a quartz crystal microbalance (QCM) in both science and technology [8]. In the present paper, a new method is proposed for the determination of quinine based on the use of a specially designed ring-coated piezoelectric crystal sensor. The method is simple and sensitive and enables submicrogram amounts of quinine to be determined.
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