Determination of Pydiflumetofen Residues in Some Foods of Plant and Animal Origin by QuEChERS Extraction Combined with Ultra-Performance Liquid Chromatography–Tandem Mass

Abstract

A rapid and effective analytical method for determination of pydiflumetofen residues in some foods of plant and animal origin (grapes, tomatoes, wheat, pork, milk, and eggs) was developed using a modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) sample preparation procedure followed by ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC–MS/MS). Acetonitrile was served as the extraction solvent, and an octadecylsilane-dispersive solid-phase extraction (C18-dSPE) was used to cleanup the analyte, and then detected by UPLC–MS/MS. Pydiflumetofen was eluted within 3.0 min from the HSS T3 chromatography column connected to an electrospray ionization source in positive mode. The linearity of the method was excellent (R2 ≥ 0.992) in the pydiflumetofen concentration range of 10–1000 μg kg−1. The recoveries of spiked pydiflumetofen (10, 100, and 1000 μg kg−1) from the matrices were satisfactory, being between 72.0 and 110.3%, and all with relative standard deviation values of < 15.1%. The limit of quantification for pydiflumetofen was 10 μg kg−1. This study provides a method for the routine monitoring of pydiflumetofen.