Abstract
A product operator description of the nuclei in an ensemble of molecules undergoing intermolecular exchange during the spin-lock period of TOCSY is presented. Experimental measurements of the transfer of magnetization from the CH2 protons in N-acetylglycine to the solvent water protons, via exchange of the NH proton with water protons during the spin-lock period in TOCSY, are shown to be in agreement with theoretical predictions at lower pH values (7.85-9.54) where the rate constants for NH-water exchange are known. Measurements at higher pH (up to 11.03) indicate that the highest rate constant for exchange that can be determined by this technique is τA-1 ~ 4000 s-1.Key words: product operator, density matrix, intermolecular exchange, TOCSY, NMR.
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