Abstract
Abstract Prednisolone sodium phosphate cannot be extracted as such from aqueous solutions because of its polar characteristics. It can be extracted as its ion pair, using a relatively high molecular weight aliphatic amine as counter ion. Liquid formulations of prednisolone sodium phosphate are rapidly assayed by incorporating the sample as immobile phase in a partition chromatographic column. Prewash with suitable organic solvents removes extractable adjuvants; the phosphate ester is eluted with a solution of trihexylamine hydrochloride in methylene chloride. The ester is extracted from the eluate with sodium hydroxide solution, and measured by ultraviolet spectrophotometry.
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