Abstract
A new determination method for polyhexamethylene biguanide hydrochloride (PHMB) using a lactone-rhodamine B (L-RB) based fluorescence optode has been developed. The optode membrane consists of 2-nitrophenyl octyl ether as a plasticizer, L-RB, and poly (vinyl chloride). The optode responds to tetrakis (4-fluorophenyl) borate, sodium salt (NaTPBF) in the μM range. The fluorescence intensity of the L-RB film for PHMB solution containing 20 μM NaTPBF decreased linearly as the concentration of the PHMB solution increased in the concentration range from 0 to 8.0 μM, which shows that PHMB with a concentration range of 0 to 8.0 μM is determined by the L-RB film optode. The concentration of PHMB in the contact lens detergents by the proposed method was in accord with its nominal concentration.
Highlights
Polyhexamethylene biguanide hydrochloride (PHMB), a kind of a cationic polyelectrolyte (CP), is very useful for disinfectants in a contact lens detergent (CLD) and sanitizers for swimming pools.Many analytical methods for PHMB have been studied [1,2,3,4,5,6,7,8,9,10,11,12]
PHMB is determined by measuring the decrease of concentration of free NaTPBF by the optode based on lactone-rhodamine B (L-RB) film
We examined the response of the optode based on L-RB film to NaTPBF
Summary
Polyhexamethylene biguanide hydrochloride (PHMB), a kind of a cationic polyelectrolyte (CP), is very useful for disinfectants in a contact lens detergent (CLD) and sanitizers for swimming pools. The lower determination concentration of several analytical methods for PHMB is above a few ppm, and the methods have very tedious operation procedures and use very toxic reagents frequently. A highly sensitive HPLC method with a solid phase extraction and an evaporative light scattering detector, whose lower detection limit is 0.1 ppm (0.45 μM), has been reported for the determination of PHMB in CLDs [4]. A simpler and low-cost analytical method with a low amount of used reagent solution and waste for the measurement of PHMB in CLDs using a chemical sensor is very helpful. A highly sensitive electroanalytical sensor for PHMB by using adsorptive voltammetry as reported by Hattori et al did not apply to the determination of PHMB in CLDs [6]. We have developed the determination method of PHMB in CLDs using an optode based on L-RB film
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