Abstract
The determination of the total volume of the circulating blood or plasma is assuming increasing importance from both the clinical point of view and that of research (Erlanger,<sup>1</sup>Rowntree, Brown and Roth,<sup>2</sup>Stander<sup>3</sup>). A study of the variation of the blood volume in pregnancy having been projected in this laboratory, it became necessary to investigate the methods for determination of blood volume. This paper deals with the results of the investigation. The extensive literature on the subject discloses two basically different methods in use: the carbon monoxide method of Haldane and Smith<sup>4</sup>and the dye method of Keith, Rowntree and Geraghty.<sup>5</sup>When using the former method, one must consider myohemoglobin (Whipple<sup>6</sup>), the dependence on environmental temperature (Barcroft et al.<sup>7</sup>), the time lag in saturation of the hemoglobin in the splenic spaces (Barcroft and Barcroft<sup>8</sup>) and the local differences in cell concentration (Lamson and Nagayama<sup>9</sup>). An analysis of the data obtained
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
