Abstract
In this study, the pKa value of vemurafenib was determined by the dependence of the retention factor on the pH of the mobile phase. The change of pKa in the different acetonitrile fraction ranging between 57.5 and 62.5% (v/v) was studied by using an LC-UV method. Additionally, a simple, reliable, and rapid UPLC method has been developed for the determination of vemurafenib in human urine. Efavirenz was used as an internal standart. For vemurafenib and efavirenz, selectivity factors were found as 1.204. The asymmetry and capacity factors were obtained as 1.100 and 7.532 for vemurafenib.
 Vemurafenib was exposed to thermal, photolytic, hydrolytic, and oxidative stress conditions, and the stressed samples were detected by LC/MS/MS method.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
