Abstract
In this study, a simple and sensitive induction period based kinetic spectrophotometric method is reported for determination of trace amounts of piroxicam (PX). This method is based upon the inhibition effect of PX on the catalytic oxidation of m-creosol purple (MCP) with periodate. In the presence of PX, an induction period appears in the reaction system, which is proportional to the PX concentration. The decolorization of MCP at 525 nm is used to monitor the reaction spectrophotometrically. Under the optimum conditions, PX can be determined in the range of 1–12.5 μM (0.33–4.14 μg mL-1), with a 3σ detection limit of 0.54 μM (0.18μg mL-1). The relative standard deviations for six replicate determinations of 1.25, 5.0, and 10.0 μM piroxicam are 1.03 %, 0.28 %, and 0.22 %, respectively. This method could successfully be used in the determination of PX in various pharmaceutical products.
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