Abstract
Type 1 Diabetes Mellitus (T1DM) disorganization of glucose equilibrium distinguishes by autoimmune disruption of the insulin producing pancreatic β-cell that constantly leads to insulin scarcity and resulting hyperglycemia Objective: To determine the physiological, biochemical, and anti-oxidant status in Type 1 Diabetes Mellitus Patients. Methods: It is a comparative study. 60 diabetic patients and 50 Samples of healthy individuals were taken from Nawaz Sharif Hospital. Blood samples (5.0 ml) were obtained and centrifuged at 4000 rpm for 10 minutes to separate the serum. Glutathione (GSH), Catalase (CAT), Superoxide Dismutase (SOD), Malondialdehyde (MDA), Nitric oxide (NO), micronutrients (Vitamin A, Vitamin C and Vitamin E) and Electrolytes was determined. Results: MDA level is progressively higher in T1DM (14.01±0.06) as compared to control group (1.27±0.21) (P- Value 0.000). GSH status is notably reduced in diabetic patients (0.15±.05) as compared to normal (6.24±0.33). Comparable anti-oxidant catalase is reduced (2.82±.04) in affected individuals as compared to normal individuals 4.19±1.09. SOD level was remarkably marked up to (13.52±3.21) in susceptible persons as compared to normal (2.15±0.23). Vitamin A level was markedly reduced to (1.62±0.26) in patients as compared to healthy individuals (7.18±0.33). Conclusions: T1DM patients particularly showed reduced amounts and competency of antioxidant protections due to elevated consumption of specific anti-oxidant components such as low level of intracellular glutathione and Catalase and primarily low levels of vitamin A, vitamin E and vitamin C and exalted level of MDA, SOD and NO.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
