Abstract
Capillary electrophoresis (CE) was used for the determination of ionisation constants (p K a) of a variety of organic bases in aqueous acetonitrile solutions over the range 0–60% (v/v) acetonitrile. These bases are used as test compounds in HPLC column evaluation, thus knowledge of their p K a in hydro–organic solutions is useful. The base p K a decreased with acetonitrile concentration and significant shifts from the aqueous p K a (up to −0.8) were found using 60% acetonitrile. The CE application was confirmed to be very suitable for fast and accurate p K a measurement in aqueous organic solutions.
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