Abstract
BackgroundPostprandial high triglyceride (HTG), marking elevated level of remnant cholesterol (RC), is an independent risk factor of coronary heart disease (CHD). The postprandial cut-off points for HTG and high RC (HRC) after a daily meal are recommended as 2.0 mmol/L and 0.9 mmol/L, respectively, by the European Atherosclerosis Society (EAS), while those after a high-fat meal in Chinese subjects were not explored.MethodsNinety subjects, including 60 CHD patients (CHD group) and 30 non-CHD controls (CON group), were enrolled in this study. Serum levels of blood lipids, including calculated RC, were monitored at 0, 2, 4 and 6 h after a high-fat meal with 800 kcal and 50 g fat. Analysis of c-statistic was used to determine the cut-off points for postprandial HTG and HRC.ResultsPostprandial levels of triglyceride (TG) and RC significantly increased and peaked at 4 h after a high-fat meal in two groups, although those in CHD group were significantly higher (P < 0.05). The optimal cut-off point to predict HTG at 4 h corresponding to fasting TG ≥ 1.7 mmol/L was 3.12 mmol/L, and that to predict HRC at 4 h corresponding to fasting RC ≥ 0.8 mmol/L was 1.36 mmol/L. According to the new cut-off points, the omissive diagnosis rates of postprandial HTG and HRC decreased obviously.ConclusionThe cut-off points of postprandial HTG and HRC in Chinese subjects after a high-fat meal were higher than those after a daily meal recommended by the EAS, indicating that specific cut-off points should be determined after a certain high-fat meal.
Highlights
According to 2016 Chinese guideline for the management of dyslipidemia in adults, appropriate triglyceride (TG) level is defined as fasting TG
Study subjects Ninety subjects, including 60 documented coronary heart disease (CHD) patients (CHD group) and 30 non-CHD controls (CON group), were recruited in this study in the Department of Cardiovascular Medicine of the Second Xiangya Hospital, Statistical analysis Quantitative variables were expressed as mean ± standard deviation (SD) unless were explained, and qualitative variables were expressed as numbers and percentages
Clinical characteristics and fasting blood lipids of two groups There were no significant difference in age, gender, body mass index (BMI), systolic or diastolic blood pressure, heart rate, percentage of overweight or smoking, and fasting glucose level between two groups
Summary
According to 2016 Chinese guideline for the management of dyslipidemia in adults, appropriate triglyceride (TG) level is defined as fasting TG
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