Abstract
A simple procedure for the determination of nitrofurantoin in urine using second derivative spectroscopy is described. The method consists of direct extraction of the non-ionized form of the drug by the use of ethyl acetate, and determination of the nitrofurantoin concentration by measuring the amplitude of the second derivative peak. The method has a detection limit of 1.5 μg ml , with recovery of 99.3% and a standard curve that is linear to 50 μg ml .
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