Determination of nephrotoxic effects due to Sugammadex and Rocuronium administration in rats

Abstract

Background: Nowadays, neuromuscular blocker rocuronium and antagonizing sugammadex are being used in anesthesia practice. Rocuronium and sugammadex complexes are eliminated via the kidneys. The aim of this study was to investigate the effects of sugammadex and rocuronium plus sugammadex on histopathological evaluation and antioxidant status of kidney tissue for nephrotoxic effect. Material and method: The study included 32 Sprague-Dawley type rats. The experimental animals were randomized into four groups with equal numbers each containing 8 rats as follows; Sham Group 1, Control Group 2, Sugammadex Group 3, Rocuronium plus sugammadex Group 4. Kidneys were excised after practise. Kidney tissue histopathological evaluation and antioxidant status (measurements of MDA and GSH levels) were investigated. Results: In group 4 led to a insignificant decrease in GSH levels compared to other groups. MDA for Group 4 showed a statistically significant difference compared to all other groups. Histopathological evaluation in group 4, an increase in vascular congestion was detected and degeneration was observed in dilated tubules and tubule epithelium. In addition, dilatation was observed in the glomerular capillaries and the veins in the medulla region. Conclusion: According to our findings, Rocuronium plus sugammadex in the dose ranges used in the studies, caused histopathological degeneration in the kidneys.