Abstract
Quartz crystal resonator (QCR) was used to identify the mode of interactions between small DNA-binding molecules and calf thymus DNA (ctDNA) according to the alteration of the relative viscosity of the solution. The differential series resonant frequencies of a 10-MHz QCR mounted in a cell containing DNA and various DNA-binding molecules at different concentrations including DNA-intercalators: ethidium bromide (EB), planar platinum(II) quaterpyridine complex, [Pt(QP)](CF 3SO 3) 2 (QP=2,2′:6′,2″:6″,2″′-quaterpyridine), ruthenium(II) quinonediimine complex of cyclam (cyclam=1,4,8,11-tetraazacyclotetradecane), [Ru(cyclam)(pqdi)]·(ClO 4) 2 (pqdi=9,10-phenanthroquinonediimine, pqdi) as well as groove binder, Hoechst 33342, separately were measured. Compared to traditional viscosity measurement method, the use of QCR has the benefits of automation, time saving, high sensitivity and stability, as well as easy operation and cleanup. Extreme viscous sample can also be conducted by QCR.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
