Abstract
In the work, we offer a brief report by research results demonstrating correlations between energy status of peripheral blood lymphocytes and functional state of vital tissues mitochondria. Basing on our preliminary data, showing correlations between succinate dehydrogenase (SDH) activity in peripheral blood lymphocytes and speed or duration of pyridine nucleotides reduction in mitochondria of rat brain and liver tissues, we propose an idea of using cytobiochemical method of SDH estimation in peripheral blood lymphocytes for evaluation of tissue mitochondria status. The method could be successfully used in clinical practice for early revealing of energy metabolism disturbances that allows preventing disease development and optimizing the diseases therapy.
Highlights
Energy exchange is essential for normal functioning of organism and it’s dysfunction triggers development of pathological processes and aging [1,2]
We offer a brief report by research results demonstrating correlations between energy status of peripheral blood lymphocytes and functional state of vital tissues mitochondria
Basing on our preliminary data, showing correlations between succinate dehydrogenase (SDH) activity in peripheral blood lymphocytes and speed or duration of pyridine nucleotides reduction in mitochondria of rat brain and liver tissues, we propose an idea of using cytobiochemical method of SDH estimation in peripheral blood lymphocytes for evaluation of tissue mitochondria status
Summary
Energy exchange is essential for normal functioning of organism and it’s dysfunction triggers development of pathological processes and aging [1,2]. The major cellular energy sources are mitochondria. Mitochondria utilize carbohydrates, lipids and proteins degradation products to produce high-energy substances (ATP, GTP, phosphocreatine, etc.) and water. Energy of ATP is used for various vital cellular processes. Lipid and carbohydrate exchanges are interrelated in mitochondria via Krebs cycle. Mitochondria are regulators of calcium homeostasis, cell acid-alkali balance, ROS and nitric oxide production. These organelles participate in apoptosis and xenobiotic biotransformation [3]. Mitochondrial dysfunction leads to ATP depletion but metabolism disruption
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