Abstract
This study describes the spectrophotometric quantification of methimazole in tablets using zero-order absorption spectrophotometry and first derivative spectrophotometry methods. In preliminary experiments, linearity range was found between 2.0-24.0 µg/mL in zero-order spectrophotometry and first-order derivative spectrophotometry. Calibration curves were obtained by measurements of the zero-order absorbances and their first derivative values at 260.0 and 269.0 nm for the zero-order spectrophotometry and first derivative spectrophotometry, respectively. The recovery and relative standard deviations were calculated as 103.3 % and 2.18 % for UV absorption spectrophotometry and 98.0% and 0.64% for first derivative spectrophotometry, respectively. The proposed techniques were used for the analysis of tablets preparations. The methods proposed in this study were verified by analyzing validation test samples containing methimazole. Determination results showed that the applied methods were found to suitable for the quantitation of the related drug.
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