Determination of macrophage inflammatory protein-1α expression in sera from patients with classic Kaposi's sarcoma in Xinjiang Uygur Autonomous Region

Abstract

Objective To disclose the relationship between the expression of macrophage inflammatory protein-1α (MIP-1α) and the initiation of classic Kaposi's sarcoma.Methods Serum samples were collected from 16 patients with Kaposi's sarcoma,20 patients with herpes zoster,and 20 healthy controls.Enzyme-linked immunosorbent assay was conducted to determine the level of MIP-1α in these samples.Statistitical analysis was done by using the SPSS version 17.0 software.Analysis of variance and rank sum test were carred out to compare the serum level of MIP-1α among these subjects.Results The serum level of MIP-1α was (23.20 ± 0.95) pg/ml in the patients with Kaposi's sarcoma,significantly lower than that in the patients with herpes zoster and healthy controls ((47.21 ± 2.83) pg/ml and (49.14 ± 12.37) pg/ml,respectively,both P ＜ 0.05).No statistical difference was observed between the patients with herpes zoster and healthy controls (P ＞ 0.05).Conclusion The attenuated expression of MIP-1α may be associated with the initiation of Kaposi's sarcoma.