Determination of L‐Vesamicol in Serum Samples Using Enantioselective, Potentiometric Membrane Electrodes Based on Antibiotics

Abstract

Enantioselective, potentiometric membrane electrodes (EPMEs) based on antibiotics are proposed for the enantioanalysis of L‐vesamicol. A carbon paste was modified with antibiotics (vancomycin, teicoplanin, and teicoplanin modified with acetonitrile), as chiral selectors. The EPMEs based on antibiotics were reliably used for enantiopurity tests of L‐vesamicol using the direct potentiometric technique. The following linear concentration ranges: 1.0×10−6–1.0×10−4, 1.0×10−6–1×10−3 and 1×10−7−1×10−2 mol/L; and detection limits: 1.1×10−7, 9.6×10−8, and 3.6×10−8 mol/L were determine for vancomycin, teicoplanin, and teicoplanin modified with acetonitrile–based EPMEs, respectively. The proposed EPMEs were applied for the enantioanalysis of L‐vesamicol in urine samples.