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Abstract
Determination of in vitro hepatotoxicity of two plants of the Apocynaceae family Although toxicity has been ascribed to Acokanthera oppositifolia and Tabernaemontana elegans, no data exists concerning its potential hepatotoxic effects. Using a multi-parametric assay it was observed that hot water and methanol extracts of A. oppositifolia and T. elegans decreased cell viability, destabilized the mitochondrial membrane and induced strong apoptotic signals.
Highlights
Note: This paper was initially delivered at the Faculty of Education and Department of Physiology at the University of Pretoria, Groenkloof Campus, South Africa on 16 October 2013
Using a multi-parametric assay it was observed that hot water and methanol extracts of A. oppositifolia and T. elegans decreased cell viability, destabilized the mitochondrial membrane and induced strong apoptotic signals
Warm water ekstrakte was voorberei deur om plantmateriaal in kokende gedistileerde water (10% m/v) vir 15 min te roer
Summary
Syntax Warning: PDF file is damaged - attempting to reconstruct xref table... Bepaling van in vitro hepatotoksisiteit van twee plante van die Apocynaceae familie Affiliations: 1Department of Pharmacology, University of Pretoria, South Africa How to cite this article: Cordier, W.
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