Abstract
Optimal digoxin therapy has been facilitated by the development of an enzyme immunoassay (EIA) kit for digoxin by monitoring its blood concentrations. Clinically, there were some cases responsive to digoxin at the serum level of 0.3 ng/ml or less. However, at present, no EIA kit can determine such concentrations accurately and precisely. Thus, we conducted astudy on the determination of the lower levels of digoxin by a modified MARKIT method (one of the competitive binding EIA) by using a dilution method of antibody. The results showed that the modified MARKIT method can be clinically used for an accurate and precise (CV 10%) determination of the serum digoxin levels of 0.1 to 2.0ng/ml.
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