Abstract
An electrochemical method has been successfully demonstrated for sensitive determination of lisinopril with β-cyclodextrin-graphene oxide-SO3H composite modified glassy carbon electrode (β-CD/GO-SO3H/GCE). Cyclic voltammetry, differential pulse voltammetry, and chronocoulometry were used to investigate the electrochemical behavior of lisinopril at β-CD/GO-SO3H/GCE. The cyclic voltammetric results indicate that β-CD/GO-SO3H/GCE can remarkably enhance electroactivity toward the oxidation of lisinopril in buffer solutions. The electrochemical behavior was further exploited as a sensitive detection scheme for the lisinopril determination by differential-pulse voltammetry. Under optimized conditions, the concentration range and detection limit were 0.21–190.4 and 0.11 µM (S/N = 3), respectively. The method was successfully applied to assay the drug in human serum.
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