Abstract
Determination of Level of 25-Hydroxy Vitamin D3 in Patients with Multiple Sclerosis and Its Effect on Disease Activity
Highlights
Multiple sclerosis is an inflammatory, demyelinating disease of the CNS and it’s characterized by myelin loss, inflammatory lesions, and varying degrees of axonal pathology[1]
The results shows that, only significant finding was that, supplements for Vitamin D significantly increased its mean level in patients with Multiple Sclerosis (P < 0.05)
During the blood sample taking process, two samples’ serum were hemolyzed after blood gel tubes were separated by centrifuge, indicating an error had happened during blood sample taking process from those two patients and they are excluded from the study
Summary
Multiple sclerosis is an inflammatory, demyelinating disease of the CNS and it’s characterized by myelin loss, inflammatory lesions, and varying degrees of axonal pathology[1]. Despite the unknown etiology, there is an increasing evidence for the possible association between MS and vitamin D deficiency in recent years[2] This proves correlates the role from Vitamin-D in the expansion of MS1. Vitamin D deficiency and increased disease activity have been related to established relapsing-remitting multiple sclerosis (RRMS).[3] It is currently established that MS is a T helper type 1 (Th1) and Th17- driven immune-mediated disease[4]. This was illustrated by immune cell infiltration and accompanying inflammatory processes leading to damage of myelin[4]. All from these immunomodulatory wares of 1, 25(OH), 2D3 can be leading to the protection of objective tissue in autoimmune diseases[2]
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