Abstract
Objective To establish a method for determining the ketoconazole in ketoconazole and triamcinolone acetonide cream.Methods HPLC was adopted.The determination was performed on Shimpack VP-ODS C18 under the following conditions:the mobile phase was methanol and pH 6.8 phosphate buffer (80:20) ; the flow rate was 1.0 ml · min-1; and the detection wavelength was 254 nm.Results The calibration curve of ketoconazole was linear within the concentration range of 19.34 ～ 116.10 μg · ml-1 (r=0.9999),with an average recovery rate of 100.29％(RSD=0.26％).Conclusions This method is specific,accurate,and sensitive and can be used to control the quality of ketoconazole and triamcinolone acetonide cream. Key words: Ketoconazole and triamcinolone cream; Content determination of ketoconazole; HPLC
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