Abstract
Objective: This study was conducted to compare IL-31 serum levels in allergic rhinitis (AR) patients and normal controls as well as according to severity of AR. Materials and Methods: The subjects, normal controls and AR patients, were defined by history taking. Blood were collected from subjects and patients with AR. Serum was centrifuged and analyzed for IL-31 using enzyme linked immunosorbent assay (ELISA) kits. 70 samples of normal controls and 70 samples of AR were collected respectively. Results and Discussion: The result showed that IL-31 serum level was higher in allergic rhinitis patients, mean (SD) 4107.70 (16961.51) as compared with normal controls 2195.55 (9016.57), however it was not statistically significance with p-value, 0.406 by using independent-T test. The result also showed no significant difference of IL-31 levels according to severity of AR with p-value, 0.245 by using Mann-Whitney test. Conclusions: IL-31 serum level was higher in AR patients; however it was not statistically significant. There was also no significant difference of IL-31 levels between the severity of AR. Further study which obtain the larger sample sizes should be done to get better findings.Bangladesh Journal of Medical Science Vol.14(4) 2015 p.359-362
Highlights
Allergy refers to a tendency to immunologically respond to many common naturally occurring ingested and inhaled allergens with the continual production of immunoglobulin E (Ig E) antibodies
The result showed no significant differences for Interleukin 31 (IL-31) levels for allergic rhinitis (AR) and normal controls but, we observed that serum from AR patients induce higher levels of IL-31 than normal controls
Many studies reported the presence of IL31 in atopic dermatitis (AD) the relationship between IL-31 and AR is still remain unclear,[6,7,8] IL31 was closely related to dermatitis, AD and nonatopic dermatitis as shown in vivo animal[9]
Summary
Allergy refers to a tendency to immunologically respond to many common naturally occurring ingested and inhaled allergens with the continual production of immunoglobulin E (Ig E) antibodies. The immune responses are controlled by the cytokines. This study was undertaken to demonstrate the level of IL-31 among the local population in Malaysia and to compare them with normal controls as well as according to severity of AR. A comparative cross sectional study was conducted in 2011 among patients with allergic rhinitis who met Allergic Rhinitis and its Impact on Asthma (ARIA) classification criteria for AR. They were taken from the Otorhinolaryngology-Head & Neck Surgery (ORL-HNS) clinic in Hospital University Sains Malaysia (HUSM). Normal control subjects were recruited among healthy local people in HUSM, who did not have any history or symptoms of AR.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
