Determination of induction period and crystal growth mechanism of dexamethasone sodium phosphate in methanol–acetone system

Abstract

The induction period of dexamethasone sodium phosphate at different supersaturation was experimentally determined in a methanol–acetone system. The laser monitoring observation technique was used to determine the appearance of the first nucleus in solution. The effect of solution composition on induction period was discussed. Based on classical homogeneous nucleation theory, the solid–liquid interfacial tension and surface entropy factor were calculated from the induction period data. The experimentally determined values of interfacial tension are in agreement with the theoretical values predicted by the Mersmann equation. It was found that the nucleus of dexamethasone sodium phosphate grows continuously in pure methanol and turns from continuous growth to birth and spread growth with increasing acetone content in a methanol–acetone mixture.