Abstract

AbstractIn pH 4.2–5.2 HOAc‐NaOAc buffer solution, Ag+ reacted with dihalogenated fluorescein (DHF) dyes to form a 1:2 anionic complex. This anionic complex could further react with hyoscine butylbromide (HBB) to form 1:1 ion‐association complex, which resulted in the significant enhancement of resonance Rayleigh scattering (RRS) intensity. Therefore, a novel method for the determination of HBB by resonance Rayleigh scattering (RRS) coupled with flow injection analysis (FIA) technique has been established. The present method had been applied to determine HBB in capsules and the results were in good agreement with those obtained by the literature method.

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