Abstract
Retention behavior and specific hydrophobic surface area of some new derivatives of (4,5-Diaryl-1,2,4-triazole) acrylic acid-3 in a reversed-phase thin layer chromatographic system have been determined. Using organic-aqueous eluent systems with addition of formic acid as mobile phases, a linear relationship between the volume fraction of organic modifier and the retention parameter (RM) was established for each solute over the whole examined range of methanol and acetone concentrations and the limited range of acetonitrile content in the mobile phase. For the last system used, the parabolic dependence of this relationship was additionally examined. This allowed determining chromatographic lipophilicity parameters: RMW values by extrapolation technique and φ0 by interpolation technique for each organic modifier applied in the mobile phase. The effect of different mobile–phase modifiers (methanol, acetone, acetonitrile) on chromatographic lipophilicity parameters has been studied.
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