Abstract
The aim of this study was to demonstrate the good correlation between free serum concentrations of carbamazepine obtained by ultrafiltration and protein precipitation with sulphosalicylic acid. Serum samples from 37 outpatients chronically treated with carbamazepine were analysed. Free carbamazepine was determined by fluorescent polarization immunoanalysis. The mean free serum concentrations obtained by each technique were compared using the t-test for paired samples. The mean free serum concentrations of carbamazepine obtained by ultrafiltration and protein precipitation were 1.61 and 1.75 mgL−1, respectively. No significant difference was found between the two methods. There was good correlation (r = 0.97; 95% confidence interval = 0.95-0.99) between the free serum concentrations obtained by each separation method. Protein precipitation with sulphosalicylic acid could be used instead of ultrafiltration to obtain free serum carbamazepine. It gives similar results and is simpler, quicker and cheaper.
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