Abstract
Free formaldehyde in cosmetic samples can be determined by HPLC and post-column derivatisation as a lutidine derivative. Applying this method to nail varnishes results in poor reproducibility. It is demonstrated that most of the formaldehyde determined is generated by hydrolysis of the resin in aqueous solution during sample clean-up, extraction and determination procedures. The hydrolysis is slowest in acidic solution at low temperature. The formaldehyde concentration is thus a function of the method of determination. Kinetic evaluation of its formation by hydrolysis shows that the initial concentration of free formaldehyde in the resin is below 100 ppm.
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