Abstract
The aim of the present work was to investigate the exposure to the medical and industrial toxic chemicals. The research was carried out on hair, nail and blood samples in a panel of 40 healthy volunteers aged 7 to 77 with an average of 45 ± 19 years (18 women (45%) and 22 men (55%)). All of these individuals had not received medication for at least 1 year, including antibiotics and psychotropic. This study was realized from July 2013 to March 2014 in Beijing, China. The method for an accurate and reliable screening of medical and an industrial toxic chemical was based on detection and assay by ultra-high performance liquid chromatography with UV detection type of diode arrays. Also more than 10,000 toxic molecules commonly found in western industrial countries were screened by coupling gas chromatography and mass spectrometry. The main results indicate that the molecules analyzed are mainly antibiotic (Gentamycine and Tobramycine), antidepressant (Amitriptylin and its metabolites), narcotic (MDMA and Clonitazene), ingredient in cosmetics (Benzenediol and Benzoic acid), insecticide (Carbamate derivative), ketamine, chlorhexidine and phthalate derivatives. There are no detailed documented baseline data of the analysis of medical and Industrial toxic pollutants in hair, nail and blood samples in Beijing; however, this study should be completed on samples from other provinces of China. This study is the first of its kind. Therefore, further studies should be conducted in other cities and provinces of China to be compared with each other.
Highlights
Over the last few years, the determination of toxics in hair has been the subject of continues in the biomedical and environmental sciences [1]
The main results indicate that the molecules analyzed are mainly antibiotic, ingredient in cosmetics and antidepressant agent
The search for drug products showed the presence of two antibiotics in the two biological matrixes: hair and nails, gentamycine and tobramycine (Figures 1-3)
Summary
Over the last few years, the determination of toxics in hair has been the subject of continues in the biomedical and environmental sciences [1]. It should be noted that human hair is an attractive biological material because of the simplicity of sampling, transport and handling as well as providing information about concentration of some element that are considerably more concentrated in hair than in other biological materials, which makes analysis easier [2]. Nail tissue is rich in fibrous proteins that contain keratins such as cysteine residues. Their roots are highly influenced by health status of the cells whereas blood and other body fluids give transient concentrations; human nails provide a continuous record of elemental concentration. Nails are easier to sample, transport and store since they do not require any external conditions unlike body fluids that are prone to contaminations
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