Abstract
The enantiomeric purity of twelve commercial 14C- and 3H-labeled L-α-amino acids was determined using reverse isotope dilution analysis. The technique utilized reversed-phase (RP) thin-layer chromatography (TLC) and beta-cyclodextrin (β-CD) in the mobile phase to separate D- and L-amino acids as their 5-dimethylamino-1-naphtalene sulfonyl (dansyl, DNS) derivatives. In all cases, the L-amino acid was contaminated with the D-isomer. This is the first report of the resolution of N-DNS-Dl-tyrosine and N-(α)-DNS-Dl-lysine using this methodology. © 1998 John Wiley & Sons, Ltd.
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