Abstract
N‐3,5‐Dinitrobenzoyl(DNB)‐(R)‐phenylglycinol (Sel 1) and its silylation product (Sel 2) were used as the HPLC chiral stationary phase (CSP) for the resolution of racemic analytes. 2,2,2‐Trifluoro‐1‐(9‐anthryl)ethanol (S1), 1,1′‐bi‐2‐naphthol (S2), and 6,6′‐dibromo‐1,1′‐bi‐2‐naphthol (S3) were separated on the CSP, but the enantiomeric purities could not be accurately determined because of low resolution (Rs). In this study, the enantiomeric purity of S1‐S3 were determined using Sel 1, Sel 2, and 1,3‐bis[(S)‐methylbutoxy] calix[4]arene‐2,4‐diol (Sel 3). These were used for 1H NMR experiments in three different solvents (CDCl3, DMSO‑d6, and acetone‑d6). The accuracy of the enantiomeric purity of S1‐S3 with Sel 2 was more than 98% when using CDCl3.
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