Determination of Enantiomeric Excess of Leucine by 13C CP-MAS Solid-State NMR

Abstract

The enantiomeric excess can be determined by many methods. One of them is nuclear magnetic resonance in solid state (SS-NMR). In this study we used the SS-NMR experiment of one-dimensional exchange spectroscopy by sideband alteration for determination of the enantiomeric excess of leucine. The density functional theory gauge-including atomic orbital calculations were used to assign all signals in 13C cross polarization magic-angle spinning spectra for two different molecules in the crystal lattice of L-leucine.